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Maxwell's is located at 1039 Washington Street in Hoboken, NJ (map) about a dozen blocks north of the Hoboken PATH station or four blocks south of the 14th Street Pier.
If you're attending NYCC, ferry service leaves for Hoboken every twenty minutes from 39th Street and 12th Avenue, directly behind the Javits Center. If you're not attending NYCC and aren't already in midtown Manhattan, PATH might be a better option.
Tickets are available at venues listed on the flyer. Sure to be the best $10 you could spend that weekend. Hope to see you there!
Update: In response to this post, there has been an outbreak of comics history over at Rip Jagger's Dojo. All passengers are advised to remain seated until comics history has come to a complete halt.